Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
Identifieur interne : 006A75 ( Main/Exploration ); précédent : 006A74; suivant : 006A76Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
Auteurs : Stuart Macgregor [Australie] ; Grant W. Montgomery [Australie] ; Jimmy Z. Liu [Australie] ; ZHEN ZHEN ZHAO [Australie] ; Anjali K. Henders [Australie] ; Mitchell Stark [Australie] ; Helen Schmid [Australie] ; Elizabeth A. Holland [Australie] ; David L. Duffy [Australie] ; MINGFENG ZHANG [États-Unis] ; Jodie N. Painter [Australie] ; Dale R. Nyholt [Australie] ; Judith A. Maskiell [Australie] ; Jodie Jetann [Australie] ; Megan Ferguson [Australie] ; Anne E. Cust [Australie] ; Mark A. Jenkins [Australie] ; David C. Whiteman [Australie] ; H Kan Olsson [Suède] ; Susana Puig [Espagne] ; Giovanna Bianchi-Scarra [Italie] ; Johan Hansson [Suède] ; Florence Demenais [France] ; Maria Teresa Landi [États-Unis] ; Tadeusz Debniak [Pologne] ; Rona Mackie [Royaume-Uni] ; Esther Azizi [Israël] ; Brigitte Bressac-De Pailleretss [France] ; Alisam Goldstein [États-Unis] ; Peter A. Kanetsky [États-Unis] ; Nelleke A. Gruis [Pays-Bas] ; David E. Elder [États-Unis] ; Julia A. Newton-Bishop [Royaume-Uni] ; D. Timothy Bishop [Royaume-Uni] ; Mark M. Iles [Royaume-Uni] ; Per Helsing [Norvège] ; Christopher I. Amos ; QINGYI WEI ; Li-E Wang ; Jeffrey E. Lee ; Abrar A. Qureshi [États-Unis] ; Richard F. Kefford [Australie] ; Graham G. Giles ; Bruce K. Armstrong [Australie] ; Joanne F. Aitken [Australie] ; JIALI HAN [États-Unis] ; John L. Hopper [Australie] ; Jeffrey M. Trent ; Kevin M. Brown ; Nicholas G. Martin [Australie] ; Graham J. Mann [Australie] ; Nicholas K. Hayward [Australie]Source :
- Nature genetics [ 1061-4036 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Association.
English descriptors
Abstract
We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and 4,387 control individuals. In this discovery phase, we confirm several previously characterized melanoma-associated loci at MC1R, ASIP and MTAP-CDKN2A. We selected variants at nine loci for replication in three independent case-control studies (Europe: 2,804 subjects with melanoma, 7,618 control subjects; United States 1: 1,804 subjects with melanoma, 1,026 control subjects; United States 2: 585 subjects with melanoma, 6,500 control subjects). The combined meta-analysis of all case-control studies identified a new susceptibility locus at 1q21.3 (rs7412746, P = 9.0 x 10-11, OR in combined replication cohorts of 0.89 (95% CI 0.85-0.95)). We also show evidence suggesting that melanoma associates with 1 q42.12 (rs3219090, P = 9.3 x 10-8). The associated variants at the 1 q21.3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETD81. Variants at the 1 q21.3 locus do not seem to be associated with human pigmentation or measures of nevus density.
Url:
Affiliations:
- Australie, Espagne, France, Israël, Italie, Norvège, Pays-Bas, Pologne, Royaume-Uni, Suède, États-Unis
- Catalogne, Hollande-Méridionale, Maryland, Massachusetts, Nouvelle-Galles du Sud, Pennsylvanie, Svealand, Victoria (État), Île-de-France, Østlandet
- Barcelone, Leyde, Melbourne, Oslo, Paris, Stockholm, Sydney
- Université de Barcelone, Université de Melbourne, Université de Sydney
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Le document en format XML
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Liu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Zhen Zhen Zhao" sort="Zhen Zhen Zhao" uniqKey="Zhen Zhen Zhao" last="Zhen Zhen Zhao">ZHEN ZHEN ZHAO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Henders, Anjali K" sort="Henders, Anjali K" uniqKey="Henders A" first="Anjali K." last="Henders">Anjali K. Henders</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Stark, Mitchell" sort="Stark, Mitchell" uniqKey="Stark M" first="Mitchell" last="Stark">Mitchell Stark</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Schmid, Helen" sort="Schmid, Helen" uniqKey="Schmid H" first="Helen" last="Schmid">Helen Schmid</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia</s1><s2>Westmead, New South Wales</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>42 aut.</sZ><sZ>51 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Westmead, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Holland, Elizabeth A" sort="Holland, Elizabeth A" uniqKey="Holland E" first="Elizabeth A." last="Holland">Elizabeth A. Holland</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia</s1><s2>Westmead, New South Wales</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>42 aut.</sZ><sZ>51 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Westmead, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L." last="Duffy">David L. Duffy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Mingfeng Zhang" sort="Mingfeng Zhang" uniqKey="Mingfeng Zhang" last="Mingfeng Zhang">MINGFENG ZHANG</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>41 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Painter, Jodie N" sort="Painter, Jodie N" uniqKey="Painter J" first="Jodie N." last="Painter">Jodie N. Painter</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R." last="Nyholt">Dale R. Nyholt</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Maskiell, Judith A" sort="Maskiell, Judith A" uniqKey="Maskiell J" first="Judith A." last="Maskiell">Judith A. Maskiell</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Jetann, Jodie" sort="Jetann, Jodie" uniqKey="Jetann J" first="Jodie" last="Jetann">Jodie Jetann</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Viertel Centre for Research in Cancer Control, Cancer Council Queensland</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>45 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Ferguson, Megan" sort="Ferguson, Megan" uniqKey="Ferguson M" first="Megan" last="Ferguson">Megan Ferguson</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Viertel Centre for Research in Cancer Control, Cancer Council Queensland</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>45 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Cancer Epidemiology and Services Research, Sydney School of Public Health, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>16 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Lund Cancer Center Department of Oncology, University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>19 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Melanoma Unit, Dermatology Department, Hospital Clinic, Institut de Investigació Biomedica August Pi Suñe, Universitat de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bianchi Scarra, Giovanna" sort="Bianchi Scarra, Giovanna" uniqKey="Bianchi Scarra G" first="Giovanna" last="Bianchi-Scarra">Giovanna Bianchi-Scarra</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Internal Medicine, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>21 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Oncology-Pathology, Karolinska Institute and Karolinska University Hospital</s1><s2>Solna, Stockholm</s2><s3>SWE</s3><sZ>22 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>INSERM, U946, Fondation Jean-Dausset-CEPH</s1><s2>Paris</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Université Paris Diderot, Sorbonne Paris Cite, Institut Universitaire d'Hématologie Paris</s1><s3>FRA</s3><sZ>23 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Institut Universitaire d'Hématologie Paris</wicri:noRegion><wicri:noRegion>Université Paris Diderot, Sorbonne Paris Cite, Institut Universitaire d'Hématologie Paris</wicri:noRegion></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>24 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Debniak, Tadeusz" sort="Debniak, Tadeusz" uniqKey="Debniak T" first="Tadeusz" last="Debniak">Tadeusz Debniak</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>International Hereditary Cancer Center</s1><s2>Szczecin</s2><s3>POL</s3><sZ>25 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>International Hereditary Cancer Center</wicri:noRegion></affiliation></author><author><name sortKey="Mackie, Rona" sort="Mackie, Rona" uniqKey="Mackie R" first="Rona" last="Mackie">Rona Mackie</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>University of Glasgow Department of Public Health</s1><s2>Glasgow</s2><s3>GBR</s3><sZ>26 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University of Glasgow Department of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Dermatology/ Dermato-Oncology Unit, Sheba Medical Center</s1><s2>Tel Hashomer</s2><s3>ISR</s3><sZ>27 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Tel Hashomer</wicri:noRegion></affiliation></author><author><name sortKey="Bressac De Pailleretss, Brigitte" sort="Bressac De Pailleretss, Brigitte" uniqKey="Bressac De Pailleretss B" first="Brigitte" last="Bressac-De Pailleretss">Brigitte Bressac-De Pailleretss</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>INSERM, U946, Fondation Jean-Dausset-CEPH</s1><s2>Paris</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Service de Genetique, Institut de Cancérologie Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>28 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut de Cancérologie Gustave Roussy</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Goldstein, Alisam" sort="Goldstein, Alisam" uniqKey="Goldstein A" first="Alisam" last="Goldstein">Alisam Goldstein</name><affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>24 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name><affiliation wicri:level="2"><inist:fA14 i1="19"><s1>Center for Clinical Epidemiology & Biostatistics, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="20"><s1>Department of Biostatistics & Epidemiology, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Department of Dermatology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>31 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name><affiliation wicri:level="2"><inist:fA14 i1="22"><s1>Department of Pathology and Laboratory Medicine, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton-Bishop">Julia A. Newton-Bishop</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1><s2>Leeds</s2><s3>GBR</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1><s2>Leeds</s2><s3>GBR</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Iles, Mark M" sort="Iles, Mark M" uniqKey="Iles M" first="Mark M." last="Iles">Mark M. Iles</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1><s2>Leeds</s2><s3>GBR</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Helsing, Per" sort="Helsing, Per" uniqKey="Helsing P" first="Per" last="Helsing">Per Helsing</name><affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Department of Dermatology, Oslo University Hospital</s1><s2>Oslo</s2><s3>NOR</s3><sZ>36 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name></author><author><name sortKey="Qingyi Wei" sort="Qingyi Wei" uniqKey="Qingyi Wei" last="Qingyi Wei">QINGYI WEI</name></author><author><name sortKey="Wang, Li E" sort="Wang, Li E" uniqKey="Wang L" first="Li-E" last="Wang">Li-E Wang</name></author><author><name sortKey="Lee, Jeffrey E" sort="Lee, Jeffrey E" uniqKey="Lee J" first="Jeffrey E." last="Lee">Jeffrey E. Lee</name></author><author><name sortKey="Qureshi, Abrar A" sort="Qureshi, Abrar A" uniqKey="Qureshi A" first="Abrar A." last="Qureshi">Abrar A. Qureshi</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>41 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kefford, Richard F" sort="Kefford, Richard F" uniqKey="Kefford R" first="Richard F." last="Kefford">Richard F. Kefford</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia</s1><s2>Westmead, New South Wales</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>42 aut.</sZ><sZ>51 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Westmead, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Cancer Epidemiology and Services Research, Sydney School of Public Health, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>16 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Aitken, Joanne F" sort="Aitken, Joanne F" uniqKey="Aitken J" first="Joanne F." last="Aitken">Joanne F. Aitken</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Viertel Centre for Research in Cancer Control, Cancer Council Queensland</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>45 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Jiali Han" sort="Jiali Han" uniqKey="Jiali Han" last="Jiali Han">JIALI HAN</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>41 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Trent, Jeffrey M" sort="Trent, Jeffrey M" uniqKey="Trent J" first="Jeffrey M." last="Trent">Jeffrey M. Trent</name></author><author><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia</s1><s2>Westmead, New South Wales</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>42 aut.</sZ><sZ>51 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Westmead, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0006901</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 12-0006901 INIST</idno><idno type="RBID">Pascal:12-0006901</idno><idno type="wicri:Area/PascalFrancis/Corpus">001760</idno><idno type="wicri:Area/PascalFrancis/Curation">004749</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001A65</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001A65</idno><idno type="wicri:doubleKey">1061-4036:2011:Macgregor S:genome:wide:association</idno><idno type="wicri:Area/Main/Merge">006F16</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227560</idno><idno type="RBID">PMC:3227560</idno><idno type="wicri:Area/Pmc/Corpus">002E08</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E08</idno><idno type="wicri:Area/Pmc/Curation">002C58</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C58</idno><idno type="wicri:Area/Pmc/Checkpoint">002303</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002303</idno><idno type="wicri:Area/Ncbi/Merge">000B88</idno><idno type="wicri:Area/Ncbi/Curation">000B88</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B88</idno><idno type="wicri:doubleKey">1061-4036:2011:Macgregor S:genome:wide:association</idno><idno type="wicri:Area/Main/Merge">006499</idno><idno type="wicri:Area/Main/Curation">006A75</idno><idno type="wicri:Area/Main/Exploration">006A75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3</title><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jimmy Z" sort="Liu, Jimmy Z" uniqKey="Liu J" first="Jimmy Z." last="Liu">Jimmy Z. Liu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Zhen Zhen Zhao" sort="Zhen Zhen Zhao" uniqKey="Zhen Zhen Zhao" last="Zhen Zhen Zhao">ZHEN ZHEN ZHAO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Henders, Anjali K" sort="Henders, Anjali K" uniqKey="Henders A" first="Anjali K." last="Henders">Anjali K. Henders</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Stark, Mitchell" sort="Stark, Mitchell" uniqKey="Stark M" first="Mitchell" last="Stark">Mitchell Stark</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Schmid, Helen" sort="Schmid, Helen" uniqKey="Schmid H" first="Helen" last="Schmid">Helen Schmid</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia</s1><s2>Westmead, New South Wales</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>42 aut.</sZ><sZ>51 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Westmead, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Holland, Elizabeth A" sort="Holland, Elizabeth A" uniqKey="Holland E" first="Elizabeth A." last="Holland">Elizabeth A. Holland</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia</s1><s2>Westmead, New South Wales</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>42 aut.</sZ><sZ>51 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Westmead, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L." last="Duffy">David L. Duffy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Mingfeng Zhang" sort="Mingfeng Zhang" uniqKey="Mingfeng Zhang" last="Mingfeng Zhang">MINGFENG ZHANG</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>41 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Painter, Jodie N" sort="Painter, Jodie N" uniqKey="Painter J" first="Jodie N." last="Painter">Jodie N. Painter</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Nyholt, Dale R" sort="Nyholt, Dale R" uniqKey="Nyholt D" first="Dale R." last="Nyholt">Dale R. Nyholt</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Maskiell, Judith A" sort="Maskiell, Judith A" uniqKey="Maskiell J" first="Judith A." last="Maskiell">Judith A. Maskiell</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Jetann, Jodie" sort="Jetann, Jodie" uniqKey="Jetann J" first="Jodie" last="Jetann">Jodie Jetann</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Viertel Centre for Research in Cancer Control, Cancer Council Queensland</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>45 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Ferguson, Megan" sort="Ferguson, Megan" uniqKey="Ferguson M" first="Megan" last="Ferguson">Megan Ferguson</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Viertel Centre for Research in Cancer Control, Cancer Council Queensland</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>45 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Cancer Epidemiology and Services Research, Sydney School of Public Health, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>16 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Lund Cancer Center Department of Oncology, University Hospital</s1><s2>Lund</s2><s3>SWE</s3><sZ>19 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Melanoma Unit, Dermatology Department, Hospital Clinic, Institut de Investigació Biomedica August Pi Suñe, Universitat de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>20 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bianchi Scarra, Giovanna" sort="Bianchi Scarra, Giovanna" uniqKey="Bianchi Scarra G" first="Giovanna" last="Bianchi-Scarra">Giovanna Bianchi-Scarra</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Internal Medicine, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>21 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Oncology-Pathology, Karolinska Institute and Karolinska University Hospital</s1><s2>Solna, Stockholm</s2><s3>SWE</s3><sZ>22 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>INSERM, U946, Fondation Jean-Dausset-CEPH</s1><s2>Paris</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Université Paris Diderot, Sorbonne Paris Cite, Institut Universitaire d'Hématologie Paris</s1><s3>FRA</s3><sZ>23 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Institut Universitaire d'Hématologie Paris</wicri:noRegion><wicri:noRegion>Université Paris Diderot, Sorbonne Paris Cite, Institut Universitaire d'Hématologie Paris</wicri:noRegion></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>24 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Debniak, Tadeusz" sort="Debniak, Tadeusz" uniqKey="Debniak T" first="Tadeusz" last="Debniak">Tadeusz Debniak</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>International Hereditary Cancer Center</s1><s2>Szczecin</s2><s3>POL</s3><sZ>25 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>International Hereditary Cancer Center</wicri:noRegion></affiliation></author><author><name sortKey="Mackie, Rona" sort="Mackie, Rona" uniqKey="Mackie R" first="Rona" last="Mackie">Rona Mackie</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>University of Glasgow Department of Public Health</s1><s2>Glasgow</s2><s3>GBR</s3><sZ>26 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University of Glasgow Department of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Dermatology/ Dermato-Oncology Unit, Sheba Medical Center</s1><s2>Tel Hashomer</s2><s3>ISR</s3><sZ>27 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Tel Hashomer</wicri:noRegion></affiliation></author><author><name sortKey="Bressac De Pailleretss, Brigitte" sort="Bressac De Pailleretss, Brigitte" uniqKey="Bressac De Pailleretss B" first="Brigitte" last="Bressac-De Pailleretss">Brigitte Bressac-De Pailleretss</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>INSERM, U946, Fondation Jean-Dausset-CEPH</s1><s2>Paris</s2><s3>FRA</s3><sZ>23 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Service de Genetique, Institut de Cancérologie Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>28 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Institut de Cancérologie Gustave Roussy</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Goldstein, Alisam" sort="Goldstein, Alisam" uniqKey="Goldstein A" first="Alisam" last="Goldstein">Alisam Goldstein</name><affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>24 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name><affiliation wicri:level="2"><inist:fA14 i1="19"><s1>Center for Clinical Epidemiology & Biostatistics, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="20"><s1>Department of Biostatistics & Epidemiology, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Department of Dermatology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>31 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name><affiliation wicri:level="2"><inist:fA14 i1="22"><s1>Department of Pathology and Laboratory Medicine, University of Pennsylvania</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton-Bishop">Julia A. Newton-Bishop</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1><s2>Leeds</s2><s3>GBR</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1><s2>Leeds</s2><s3>GBR</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Iles, Mark M" sort="Iles, Mark M" uniqKey="Iles M" first="Mark M." last="Iles">Mark M. Iles</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1><s2>Leeds</s2><s3>GBR</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Helsing, Per" sort="Helsing, Per" uniqKey="Helsing P" first="Per" last="Helsing">Per Helsing</name><affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Department of Dermatology, Oslo University Hospital</s1><s2>Oslo</s2><s3>NOR</s3><sZ>36 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name></author><author><name sortKey="Qingyi Wei" sort="Qingyi Wei" uniqKey="Qingyi Wei" last="Qingyi Wei">QINGYI WEI</name></author><author><name sortKey="Wang, Li E" sort="Wang, Li E" uniqKey="Wang L" first="Li-E" last="Wang">Li-E Wang</name></author><author><name sortKey="Lee, Jeffrey E" sort="Lee, Jeffrey E" uniqKey="Lee J" first="Jeffrey E." last="Lee">Jeffrey E. Lee</name></author><author><name sortKey="Qureshi, Abrar A" sort="Qureshi, Abrar A" uniqKey="Qureshi A" first="Abrar A." last="Qureshi">Abrar A. Qureshi</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>41 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kefford, Richard F" sort="Kefford, Richard F" uniqKey="Kefford R" first="Richard F." last="Kefford">Richard F. Kefford</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia</s1><s2>Westmead, New South Wales</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>42 aut.</sZ><sZ>51 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Westmead, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Cancer Epidemiology and Services Research, Sydney School of Public Health, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>16 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Aitken, Joanne F" sort="Aitken, Joanne F" uniqKey="Aitken J" first="Joanne F." last="Aitken">Joanne F. Aitken</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Viertel Centre for Research in Cancer Control, Cancer Council Queensland</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>45 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Jiali Han" sort="Jiali Han" uniqKey="Jiali Han" last="Jiali Han">JIALI HAN</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>41 aut.</sZ><sZ>46 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>47 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Trent, Jeffrey M" sort="Trent, Jeffrey M" uniqKey="Trent J" first="Jeffrey M." last="Trent">Jeffrey M. Trent</name></author><author><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia</s1><s2>Westmead, New South Wales</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>42 aut.</sZ><sZ>51 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Westmead, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>18 aut.</sZ><sZ>50 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term><term>Identification</term><term>Malignant melanoma</term><term>Sensitivity</term><term>Susceptibility locus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Association</term><term>Identification</term><term>Sensibilité</term><term>Mélanome malin</term><term>Echelle du génome</term><term>Locus de susceptibilité</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and 4,387 control individuals. In this discovery phase, we confirm several previously characterized melanoma-associated loci at MC1R, ASIP and MTAP-CDKN2A. We selected variants at nine loci for replication in three independent case-control studies (Europe: 2,804 subjects with melanoma, 7,618 control subjects; United States 1: 1,804 subjects with melanoma, 1,026 control subjects; United States 2: 585 subjects with melanoma, 6,500 control subjects). The combined meta-analysis of all case-control studies identified a new susceptibility locus at 1q21.3 (rs7412746, P = 9.0 x 10<sup>-11</sup>, OR in combined replication cohorts of 0.89 (95% CI 0.85-0.95)). We also show evidence suggesting that melanoma associates with 1 q42.12 (rs3219090, P = 9.3 x 10<sup>-8</sup>). The associated variants at the 1 q21.3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETD81. Variants at the 1 q21.3 locus do not seem to be associated with human pigmentation or measures of nevus density.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>France</li><li>Israël</li><li>Italie</li><li>Norvège</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Catalogne</li><li>Hollande-Méridionale</li><li>Maryland</li><li>Massachusetts</li><li>Nouvelle-Galles du Sud</li><li>Pennsylvanie</li><li>Svealand</li><li>Victoria (État)</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Barcelone</li><li>Leyde</li><li>Melbourne</li><li>Oslo</li><li>Paris</li><li>Stockholm</li><li>Sydney</li></settlement><orgName><li>Université de Barcelone</li><li>Université de Melbourne</li><li>Université de Sydney</li></orgName></list><tree><noCountry><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><name sortKey="Lee, Jeffrey E" sort="Lee, Jeffrey E" uniqKey="Lee J" first="Jeffrey E." last="Lee">Jeffrey E. Lee</name><name sortKey="Qingyi Wei" sort="Qingyi Wei" uniqKey="Qingyi Wei" last="Qingyi Wei">QINGYI WEI</name><name sortKey="Trent, Jeffrey M" sort="Trent, Jeffrey M" uniqKey="Trent J" first="Jeffrey M." last="Trent">Jeffrey M. Trent</name><name sortKey="Wang, Li E" sort="Wang, Li E" uniqKey="Wang L" first="Li-E" last="Wang">Li-E Wang</name></noCountry><country name="Australie"><noRegion><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name></noRegion><name sortKey="Aitken, Joanne F" sort="Aitken, Joanne F" uniqKey="Aitken J" first="Joanne F." last="Aitken">Joanne F. Aitken</name><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L." last="Duffy">David L. 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Whiteman</name><name sortKey="Zhen Zhen Zhao" sort="Zhen Zhen Zhao" uniqKey="Zhen Zhen Zhao" last="Zhen Zhen Zhao">ZHEN ZHEN ZHAO</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Mingfeng Zhang" sort="Mingfeng Zhang" uniqKey="Mingfeng Zhang" last="Mingfeng Zhang">MINGFENG ZHANG</name></region><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name><name sortKey="Goldstein, Alisam" sort="Goldstein, Alisam" uniqKey="Goldstein A" first="Alisam" last="Goldstein">Alisam Goldstein</name><name sortKey="Jiali Han" sort="Jiali Han" uniqKey="Jiali Han" last="Jiali Han">JIALI HAN</name><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. 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Timothy" last="Bishop">D. Timothy Bishop</name><name sortKey="Iles, Mark M" sort="Iles, Mark M" uniqKey="Iles M" first="Mark M." last="Iles">Mark M. Iles</name><name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton-Bishop">Julia A. Newton-Bishop</name></country><country name="Israël"><noRegion><name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name></region></country><country name="Norvège"><region name="Østlandet"><name sortKey="Helsing, Per" sort="Helsing, Per" uniqKey="Helsing P" first="Per" last="Helsing">Per Helsing</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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